EpiChron: Investigación en enfermedades crónicas

Grupos de investigación

Foto del grupo EPICHRON<br />
INVESTIGACIÓN EN ENFERMEDADES CRÓNICAS

EpiChron avanza en el conocimiento de la multimorbilidad para facilitar su abordaje clínico con el fin último de reducir su impacto negativo en la salud de los pacientes y en el sistema sanitario

Equipo Científico

INVESTIGADOR PRINCIPAL

Alexandra Prados, Medicina Preventiva y Salud Pública(MPySP)

EQUIPO

Paula Ara, Veterinaria; Mercedes Aza, Farmacéutica; Ana Bandrés, Farmacéutica; Kevin Bliek, Medicina Preventiva y Salud Pública(MPySP); Amaia Calderón, Epidemióloga; Mabel Cano, MPySZ; Jonás Carmona, Médico de Familia (MF); Mercedes Clerencia, Geriatra; Jesús Díez Internista; Luis Gimeno, MF; Antonio Gimeno, Epidemiólogo; Francisca González, MF; Inmaculada Guerrero, MPySP; Ignatios Ioakeim, Colaborador internacional; Clara Laguna, Estadística; Aida Moreno, MF; Victoria Pico, MF; Beatriz Poblador, Estadística; Antonio Poncel, Médico Sistemas de Información; Alejandro Santos Bioestadístico

Página web del grupo

Actividad del grupo de investigación

EpiChron es un grupo de investigación multidisciplinar del Sistema Nacional de Salud centrado en la caracterización clínico-epidemiológica de las enfermedades crónicas y la multimorbilidad a través del uso de datos de vida real y su abordaje mediante modelos de atención centrados en la persona.

Centro

Instituto Aragonés de Ciencias de la Salud

Programas

Salud pública, cronicidad, servicios sanitarios y atención primaria

Líneas de investigación

  • Caracterización de enfermedades crónicas y multimorbilidad: Enfoque poblacional a través de la Cohorte EpiChron y utilización de datos de vida real en investigación (FAIR4Health H2020)
  • Abordaje de la multimorbilidad centrado en la persona: Ensayo clínico MULTIPAP Study
  • Diseño de modelos de respuesta a la cronicidad: Principios Ariadne e Integrated Multimorbidity Care Model (EU Chrodis Joint Action)
  • Caracterización clínico-epidemiológica de COVID19 (PRECOVID Study)

Artículos publicados

Vacío

2022

Lozano-Hernández CM, López-Rodríguez JA, Rico-Blázquez M, et al. Sex differences in social support perceived by polymedicated older adults with multimorbidity. MULTIPAP study. PLoS One. 2022;17(7):e0268218. Published 2022 Jul 27. doi:10.1371/journal.pone.0268218
Malo S, Maldonado L, Rabanaque MJ, et al. Patterns of statin adherence in primary cardiovascular disease prevention during the pandemic. Front Pharmacol. 2022;13:980391. Published 2022 Nov 14.
doi:10.3389/fphar.2022.980391

Almenara-Blasco M, Carmona-Pírez J, Gracia-Cazaña T, et al. Comorbidity Patterns in Patients with Atopic Dermatitis Using Network Analysis in the EpiChron Study. Journal of Clinical Medicine. 2022;
11(21):6413. https://doi.org/10.3390/jcm11216413

Reus, X.; Sastre, M.L.; Leiva, A.; et al. C. LESS-PHARMA Study: Identifying and Deprescribing Potentially
Inappropriate Medication in the Elderly Population with Excessive Polypharmacy in Primary Care. Int. J. Environ. Res. Public Health 2022, 19, 13241. https://
doi.org/10.3390/ijerph192013241

 

Ioakeim-Skoufa, I.; Clerencia-Sierra, M.; Moreno-Juste, A.; et al. Multimorbidity Clusters in the Oldest Old: Results from the EpiChron Cohort. Int. J. Environ. Res. Public Health 2022, 19, 10180. https://doi.
org/10.3390/ijerph191610180

Gracia Gutiérrez A, Grados Saso D, Esteban Cabello EI, et al. Clinical characteristics of heart failure patients with mid-range ejection fraction. Acta Cardiol. 2022 Aug 10:1-8. doi: 10.1080/00015385.2022.2059135. Epub ahead of print. PMID: 35947112.

Del Cura-González I, López-Rodríguez JA, Leiva-Fernández F, et al; Effectiveness of the MULTIPAP Plus intervention in youngest-old patients with multimorbidity and polypharmacy aimed at improving prescribing practices in primary care: study protocol of a cluster randomized trial. Trials. 2022 Jun 9; 23(1):479. doi: 10.1186/s13063-022-06293-x. PMID:
35681224; PMCID: PMC9178530.

 

Del Cura-González I, López-Rodríguez JA, Leiva-Fernández F, et al. How to Improve Healthcare for Patients with Multimorbidity and Polypharmacy in Primary Care: A Pragmatic Cluster-Randomized Clinical
Trial of the MULTIPAP Intervention. J Pers Med. 2022 May 6;12(5):752. doi: 10.3390/jpm12050752. PMID:
35629175; PMCID: PMC9144280

Santiá P, Jansana A, Del Cura I, et al. Adherence of long-term breast cancer survivors to follow-up care guidelines: a study based on real-world data from the
SURBCAN cohort. Breast Cancer Res Treat. 2022 Mar 15. doi: 10.1007/s10549-022-06563-x. Epub ahead of print. PMID: 35290544.

Carmona-Pírez, J.; Ioakeim-Skoufa, I.; Gimeno-Miguel, A.; et al. Multimorbidity Profiles and Infection Severity in COVID-19 Population Using Network Analysis in
the Andalusian Health Population Database. Int. J. Environ. Res. Public Health 2022, 19, 3808. https://
doi.org/10.3390/ijerph19073808

 

Carmona-Pírez J, Gimeno-Miguel A, Bliek-Bueno K, et al. Identifying multimorbidity profiles associated with COVID-19 severity in chronic patients using network analysis in the PRECOVID Study. Sci Rep. 2022 Feb
18;12(1):2831. doi: 10.1038/s41598-022-06838-9. PMID: 35181720; PMCID: PMC8857317.

Carmona-Pírez J, Poblador-Plou B, Poncel-Falcó A, et al. Applying the FAIR4Health Solution to Identify Multimorbidity Patterns and Their Association with Mortality through a Frequent Pattern
Growth Association Algorithm. International Journal of Environmental Research and Public Health. 2022; 19(4):2040. https://doi.org/10.3390/ijerph19042040

2021

Gencturk M, Teoman A, Alvarez-Romero C, Martinez-Garcia A, Parra-Calderon CL, Poblador-Plou B, Löbe M, Sinaci AA. End User Evaluation of the FAIR4Health Data Curation Tool. Stud Health Technol Inform. 2021 May 27;281:8-12. 

Gimeno-Miguel A, Bliek-Bueno K, Poblador-Plou B, Carmona-Pírez J, Poncel-Falcó A, González-Rubio F, et al. (2021) Chronic diseases associated with increased likelihood of hospitalization and mortality in 68,913 COVID-19 confirmed cases in Spain: A population-based cohort study. PLoS ONE 16(11): e0259822. 

Bliek-Bueno K, Mucherino S, Poblador-Plou B, González-Rubio F, Aza-Pascual-Salcedo M, Orlando V, Clerencia-Sierra M, Ioakeim-Skoufa I, Coscioni E, Carmona-Pírez J, Perrella A, Trama U, Prados-Torres A, Menditto E, Gimeno-Miguel A. Baseline Drug Treatments as Indicators of Increased Risk of COVID-19 Mortality in Spain and Italy. International Journal of Environmental Research and Public Health. 2021; 18(22):11786. 

Jansana A, Poblador-Plou B, Gimeno-Miguel A, Lanzuela M, Prados-Torres A, Domingo L, Comas M, Sanz-Cuesta T, Del Cura-Gonzalez I, Ibañez B, Abizanda M, Duarte-Salles T, Padilla-Ruiz M, Redondo M, Castells X, Sala M; SURBCAN Group. Multimorbidity clusters among long-term breast cancer survivors in Spain: Results of the SURBCAN study. Int J Cancer. 2021 Jul 13

Leiva-Fernández, F., González-Hevilla, A., Prados-Torres, J. D., Casas-Galán, F., García-Domingo, E., Ortiz-Suárez, P., López-Rodríguez, J. A., & Pico-Soler, M. V. (2021). Identification of the multimorbidity training needs of primary care professionals: Protocol of a survey. Journal of Multimorbidity and Comorbidity

Eloísa Rogero-Blanco, Isabel Del-Cura-González, Mercedes Aza-Pascual-Salcedo, Francisca García de Blas González, Carmen Terrón-Rodas, Sergio Chimeno-Sánchez, Eva García-Domingo, Juan A. López-Rodríguez & group MULTIPAP (2021) Drug interactions detected by a computer-assisted prescription system in primary care patients in Spain: MULTIPAP study, European Journal of General Practice, 27:1, 90-96

Mucherino S, Gimeno-Miguel A, Carmona-Pirez J, Gonzalez-Rubio F, Ioakeim-Skoufa I, Moreno-Juste A, Orlando V, Aza-Pascual-Salcedo M, Poblador-Plou B, Menditto E, Prados-Torres A. Changes in Multimorbidity and Polypharmacy Patterns in Young and Adult Population over a 4-Year Period: A 2011-2015 Comparison Using Real-World Data. Int J Environ Res Public Health. 2021 Apr 21;18(9):4422. 

Jansana A, Domingo L, Ibañez B, Prados A, Del Cura I, Padilla-Ruiz M, Sanz T, Poblador B, Tamayo I, Gimeno A, Alberquilla A, Abizanda M, Comas M, Lanzuela M, Burgui R, Holgado AD, Duarte-Salles T, Moreno C, Louro J, Baquedano J, Molina C, Del Carmen Martinez M, Gorricho J, Redondo M, Castells X, Sala M. Use of health services among long-term breast cancer survivors in Spain: longitudinal study based on real-world data. J Cancer Surviv. 2021 Mar 23. 

Carmona-Pírez J, Poblador-Plou B, Ioakeim-Skoufa I, González-Rubio F, Gimeno-Feliú LA, Díez-Manglano J, Laguna-Berna C, Marin JM, Gimeno-Miguel A, Prados-Torres A. Multimorbidity clusters in patients with chronic obstructive airway diseases in the EpiChron Cohort. Sci Rep. 2021 Feb 26;11(1):4784. 

Gimeno-Feliu LA, Pastor-Sanz M, Poblador-Plou B, Calderón-Larrañaga A, Díaz E, Prados-Torres A. Overuse or underuse? Use of healthcare services among irregular migrants in a north-eastern Spanish region. Int J Equity Health. 2021 Jan 20;20(1):41. 

 

2020-2018

2020

Guerrero Fernández de Alba I, Gimeno-Miguel A, Poblador-Plou B, Gimeno-Feliu LA, Ioakeim-Skoufa I, Rojo-Martínez G, Forjaz MJ, Prados-Torres A. Association between mental health comorbidity and health outcomes in type 2 diabetes mellitus patients. Sci Rep. 2020 Nov 11;10(1):19583. doi: 10.1038/s41598-020-76546-9

Guerrero Fernández de Alba, I., Gimeno-Miguel, A., Poblador-Plou, B. et al. Association between mental health comorbidity and health outcomes in type 2 diabetes mellitus patients. Sci Rep 10, 19583 (2020). https://doi.org/10.1038/s41598-020-76546-9

Carmona-Pírez J, Poblador-Plou B, Díez-Manglano J, Morillo-Jiménez MJ, Marín Trigo JM, Ioakeim-Skoufa I, Gimeno-Miguel A, Prados-Torres A. Multimorbidity networks of chronic obstructive pulmonary disease and heart failure in men and women: Evidence from the EpiChron Cohort. Mech Ageing Dev. 2020 Oct 29;193:111392. doi: 10.1016/j.mad.2020.111392. Epub ahead of print. PMID: 33129797.

Guerrero Fernández de Alba, I., Gimeno-Miguel, A., Poblador-Plou, B. et al. Association between mental health comorbidity and health outcomes in type 2 diabetes mellitus patients. Sci Rep 10, 19583 (2020). https://doi.org/10.1038/s41598-020-76546-9

Díez-Manglano J, Berges Vidal M, Martínez Barredo L, Poblador-Plou B, Gimeno-Miguel A, Martínez Heras P, Prados-Torres A. Chronic Obstructive Pulmonary Disease and Incidence of Hip Fracture: A Nested Case–Control Study in the EpiChron CohortInt J Chron Obstruct Pulmon Dis. 2020;15:2799-2806 https://doi.org/10.2147/COPD.S270713

Leiva-Fernández F, Prados-Torres JD, Prados-Torres A, Del-Cura-González I, Castillo-Jimena M, López-Rodríguez JA, Rogero-Blanco ME, López-Verde F, Bujalance-Zafra MJ, Pico-Soler MV, Gimeno-Feliu LA, Poblador-Plou B, Martinez-Cañavate MT, Muth C; MULTIPAP Group. Training primary care professionals in multimorbidity management: educational assessment of the eMULTIPAP course. Mech Ageing Dev. 2020 Sep 15:111354. doi: 10.1016/j.mad.2020.111354. Epub ahead of print. PMID: 32946885.

Jansana A, Del Cura I, Prados-Torres A, Sanz Cuesta T, Poblador-Plou B, Gimeno Miguel A, Lanzuela M, Ibañez B, Tamayo I, Moreno-Iribas C, Padilla-Ruiz M, Redondo M, Comas M, Domingo L, Díaz-Holgado A, Salamanca FJ, Castells X, Sala M; SURBCAN group. Use of real-world data to study health services utilisation and comorbidities in long-term breast cancer survivors (the SURBCAN study): study protocol for a longitudinal population-based cohort study. BMJ Open. 2020 Sep 9;10(9):e040253. doi: 10.1136/bmjopen-2020-040253. PMID: 32912957; PMCID: PMC7482495.

Lopez-Rodriguez JA, Rogero-Blanco E, Aza-Pascual-Salcedo M, Lopez-Verde F, Pico-Soler V, Leiva-Fernandez F, Prados-Torres JD, Prados-Torres A, Cura-González I; MULTIPAP group. Potentially inappropriate prescriptions according to explicit and implicit criteria in patients with multimorbidity and polypharmacy. MULTIPAP: A cross-sectional study. PLoS One. 2020 Aug 12;15(8):e0237186. doi: 10.1371/journal.pone.0237186. PMID: 32785232.

Francisca González-Rubio, Ignatios Ioakeim-Skoufa, Beatriz Poblador-Plou, Antonio Gimeno-Miguel, Alexandra Prados-Torres, Influenza vaccination: an ally to mitigate influenza-associated risks during the coronavirus pandemicsClinical Infectious Diseases, , ciaa1190, https://doi.org/10.1093/cid/ciaa1190

Letosa-Gaudó J, González-Rubio F, Ioakeim-Skoufa I. Analytical errors due to biotin interference. Med Clin (Barc). 2020 Jul 24:S0025-7753(20)30440-1. English, Spanish. doi: 10.1016/j.medcli.2020.04.049. Epub ahead of print. PMID: 32718712.

Rodriguez-Blazquez C, João Forjaz M, Gimeno-Miguel A, Bliek-Bueno K, Poblador-Plou B, Pilar Luengo-Broto S, Guerrero-Fernández de Alba I, Maria Carriazo A, Lama C, Rodríguez-Acuña R, Cosano I, Bedoya JJ, Angioletti C, Carfì A, Di Paola A, Navickas R, Jureviciene E, Dambrauskas L, Liseckiene I, Valius L, Urbonas G, Onder G, Prados-Torres A. Assessing the Pilot Implementation of the Integrated Multimorbidity Care Model in Five European Settings: Results from the Joint Action CHRODIS-PLUS. Int J Environ Res Public Health. 2020 Jul 22;17(15):E5268. doi: 10.3390/ijerph17155268. PMID: 32707791.

Poblador-Plou B, Carmona-Pírez J, Ioakeim-Skoufa I, Poncel-Falcó A, Bliek-Bueno K, Cano-Del Pozo M, Gimeno-Feliú LA, González-Rubio F, Aza-Pascual-Salcedo M, Bandrés-Liso AC, Díez-Manglano J, Marta-Moreno J, Mucherino S, Gimeno-Miguel A, Prados-Torres A, EpiChron Group. Baseline Chronic Comorbidity and Mortality in Laboratory-Confirmed COVID-19 Cases: Results from the PRECOVID Study in Spain. Int J Environ Res Public Health. 2020 Jul 17;17(14):E5171. doi: 10.3390/ijerph17145171. PMID: 32709002.

Lozano-Hernández CM, López-Rodríguez JA, Leiva-Fernández F, Calderón-Larrañaga A, Barrio-Cortes J, Gimeno-Feliu LA, Poblador-Plou B, Cura-González ID; MULTIPAP GROUP. Social support, social context and nonadherence to treatment in young senior patients with multimorbidity and polypharmacy followed-up in primary care. MULTIPAP Study. PLoS One. 2020 Jun 24;15(6):e0235148. doi: 10.1371/journal.pone.0235148. PMID: 32579616; PMCID: PMC7314051.

Gimeno-Feliu LA, Pastor-Sanz M, Poblador-Plou B, Calderón-Larrañaga A, Díaz E, Prados-Torres A. Multimorbidity and chronic diseases among undocumented migrants: evidence to contradict the myths. Int J Equity Health. 2020 Jul 6;19(1):113. doi: 10.1186/s12939-020-01225-0. PMID: 32631325; PMCID: PMC7336489.

Ioakeim-Skoufa I, Poblador-Plou B, Carmona-Pírez J, Díez-Manglano J, Navickas R, Gimeno-Feliu LA, González-Rubio F, Jureviciene E, Dambrauskas L, Prados-Torres A, Gimeno-Miguel A. Multimorbidity Patterns in the General Population: Results from the EpiChron Cohort Study. Int J Environ Res Public Health. 2020 Jun 14;17(12):4242. doi: 10.3390/ijerph17124242. PMID: 32545876; PMCID: PMC7345112.

Gilaberte Y, Pérez-Gilaberte JB, Poblador-Plou B, Bliek-Bueno K, Gimeno-Miguel A, Prados-Torres A. Prevalence and Comorbidity of Atopic Dermatitis in Children: A Large-Scale Population Study Based on Real-World Data. J Clin Med. 2020 May 28;9(6):1632. doi: 10.3390/jcm9061632. PMID: 32481591; PMCID: PMC7356227.

Moreno-Juste A, Poblador-Plou B, Aza-Pascual-Salcedo M, González-Rubio F, Malo S, Librero López J, Pico-Soler V, Giménez Labrador E, Mucherino S, Orlando V, Menditto E, Prados-Torres A, Gimeno-Miguel A. Initial Therapy, Regimen Change, and Persistence in a Spanish Cohort of Newly Treated Type 2 Diabetes Patients: A Retrospective, Observational Study Using Real-World Data. Int J Environ Res Public Health. 2020 May 25;17(10):3742. doi: 10.3390/ijerph17103742. PMID: 32466267; PMCID: PMC7277774

Clerencia-Sierra M, Ioakeim-Skoufa I, Poblador-Plou B, González-Rubio F, Aza-Pascual-Salcedo M, Gimeno-Miguel MMA, Prados-Torres A. Do Centenarians Die Healthier than Younger Elders? A Comparative Epidemiological Study in Spain. J Clin Med. 2020 May 21;9(5):1563. doi: 10.3390/jcm9051563. PMID: 32455809; PMCID: PMC7291259.

Rogero-Blanco E, Lopez-Rodriguez JA, Sanz-Cuesta T, Aza-Pascual-Salcedo M, Bujalance-Zafra MJ, Cura-Gonzalez I; MultiPAP Group. Use of an Electronic Clinical Decision Support System in Primary Care to Assess Inappropriate Polypharmacy in Young Seniors With Multimorbidity: Observational, Descriptive, Cross-Sectional Study. JMIR Med Inform. 2020 Mar 3;8(3):e14130. doi: 10.2196/14130. PMID: 32149715; PMCID: PMC7078622.

Machón M, Mateo-Abad M, Clerencia-Sierra M, Güell C, Poblador-Pou B, Vrotsou K, Gimeno-Miguel A, Prados-Torres A, Vergara I. Multimorbidity and functional status in older people: a cluster analysis. Eur Geriatr Med. 2020 Apr;11(2):321-332. doi: 10.1007/s41999-020-00291-5. Epub 2020 Feb 17. PMID: 32297200.

Gracia Gutiérrez A, Poblador-Plou B, Prados-Torres A, Ruiz Laiglesia FJ, Gimeno-Miguel A. Sex Differences in Comorbidity, Therapy, and Health Services’ Use of Heart Failure in Spain: Evidence from Real-World Data. Int J Environ Res Public Health. 2020 Mar 23;17(6):2136. doi: 10.3390/ijerph17062136. PMID: 32210137; PMCID: PMC7143043.

Orlando V, Monetti VM, Moreno Juste A, Russo V, Mucherino S, Trama U, Guida A, Menditto E. Drug Utilization Pattern of Antibiotics: The Role of Age, Sex and Municipalities in Determining Variation. Risk Manag Healthc Policy. 2020 Jan 29;13:63-71. doi: 10.2147/RMHP.S223042. PMID: 32099490; PMCID: PMC6996207.

 

2019

Palmer K, Carfì A, Angioletti C, Di Paola A, Navickas R, Dambrauskas L, Jureviciene E, João Forjaz M, Rodriguez-Blazquez C, Prados-Torres A, Gimeno-Miguel A, Cano-Del Pozo M, Bestué-Cardiel M, Leiva-Fernández F, Poses Ferrer E, Carriazo AM, Lama C, Rodríguez-Acuña R, Cosano I, Bedoya-Belmonte JJ, Liseckiene I, Barbolini M, Txarramendieta J, de Manuel Keenoy E, Fullaondo A, Rijken M, Onder G. A Methodological Approach for Implementing an Integrated Multimorbidity Care Model: Results from the Pre-Implementation Stage of Joint Action CHRODIS-PLUS. Int J Environ Res Public Health. 2019 Dec 11;16(24):5044. doi: 10.3390/ijerph16245044. PMID: 31835691; PMCID: PMC6950053.

Gimeno-Miguel A, Gracia Gutiérrez A, Poblador-Plou B, Coscollar-Santaliestra C, Pérez-Calvo JI, Divo MJ, Calderón-Larrañaga A, Prados-Torres A, Ruiz-Laiglesia FJ. Multimorbidity patterns in patients with heart failure: an observational Spanish study based on electronic health records. BMJ Open. 2019 Dec 23;9(12):e033174. doi: 10.1136/bmjopen-2019-033174. PMID: 31874886; PMCID: PMC7008407.

Forjaz MJ, Rodriguez-Blazquez C, Guerrero-Fernández de Alba I, Gimeno-Miguel A, Bliek-Bueno K, Prados-Torres A, The Chrodis Expert Group On Multimorbidity OBO. Application of the JA-CHRODIS Integrated Multimorbidity Care Model (IMCM) to a Case Study of Diabetes and Mental Health. Int J Environ Res Public Health. 2019 Dec 17;16(24):5151. doi: 10.3390/ijerph16245151. PMID: 31861096; PMCID: PMC6950036.

Moreno Juste A, Menditto E, Orlando V, Monetti VM, Gimeno Miguel A, González Rubio F, Aza-Pascual-Salcedo MM, Cahir C, Prados Torres A, Riccardi G. Treatment Patterns of Diabetes in Italy: A Population-Based Study. Front Pharmacol. 2019 Aug 6;10:870. doi: 10.3389/fphar.2019.00870. PMID: 31447672; PMCID: PMC6691351.

Gimeno-Miguel A, Clerencia-Sierra M, Ioakeim I, Poblador-Plou B, Aza-Pascual-Salcedo M, González-Rubio F, Rodríguez Herrero R, Prados-Torres A. Health of Spanish centenarians: a cross-sectional study based on electronic health records. BMC Geriatr. 2019 Aug 19;19(1):226. doi: 10.1186/s12877-019-1235-7. PMID: 31426764; PMCID: PMC6701024.

Forns J, Cainzos-Achirica M, Hellfritzsch M, Morros R, Poblador-Plou B, Hallas J, Giner-Soriano M, Prados-Torres A, Pottegård A, Cortés J, Castellsagué J, Jacquot E, Deltour N, Perez-Gutthann S, Pladevall M. Validity of ICD-9 and ICD-10 codes used to identify acute liver injury: A study in three European data sources. Pharmacoepidemiol Drug Saf. 2019 Jul;28(7):965-975. doi: 10.1002/pds.4803. Epub 2019 Jun 6. PMID: 31172633; PMCID: PMC6618105.

Jansana APosso MGuerrero IPrados-Torres ADel Cura MICastells X, Sala M. Health care services use among long-term breast cancer survivors: a systematic review. Journal of Cancer Survivorship 2019.

Manel Pladevall‑Vila, Anton Pottegård, Tania Schink, Johan Reutfors, Rosa Morros, Beatriz Poblador‑Plou, Antje Timmer, Joan Forns, Maja Hellfritzsch, Tammo Reinders, David Hägg, ·Maria Giner‑Soriano, Alexandra Prados-Torres, Miguel Cainzos‑Achirica, Jesper Hallas, Lena Brandt, Jordi Cortés, Jaume Aguado, Gabriel Perlemuter, Bruno Falissard, Jordi Castellsagué, Emmanuelle Jacquot, Nicolas Deltour, Susana Perez‑ Risk of Acute Liver Injury in Agomelatine and Other Antidepressant Users in Four European Countries: A Cohort and Nested Case–Control Study Using Automated Health Data Sources CNS Drugs Apr;33(4):383-395. 2019

Luis Andrés Gimeno-Feliu, Amaia Calderón-Larrañaga, Esperanza Díaz, Clara Laguna-Berna,Beatriz Poblador-Plou, Carlos Coscollar-Santaliestra and Alexandra Prados-Torres. The definition of immigrant status matters: impact of nationality, country of origin, and length of stay in host country on mortality estimates. BMC Public Health 19:247;

Joan Forns, Anton Pottegård, Tammo Reinders, Beatriz Poblador-Plou, Rosa Morros, Lena Brandt, Miguel Cainzos-Achirica, Maja Hellfritzsch, Tania Schink, Alexandra Prados Torres, Maria Giner-Soriano, David Hägg, Jesper Hallas, Jordi Cortés, Emmanuelle Jacquot, Nicolas Deltour, Susana Perez-Gutthann, Manel Pladevall, Johan Reutfors. Antidepressant use in Denmark, Germany, Spain, and Sweden between 2009 and 2014: incidence and comorbidities of initiators. Journal of Affective Disorders 249; 242-252. 2019

Enrica Menditto, Antonio Gimeno Miguel, Aida Moreno, Beatriz Poblador Plou, Mercedes Aza, Valentina Orlando, Francisca González Rubio, Alexandra Prados-Torres. Patterns of multimorbidity and polypharmacy in young and adult population: Systematic associations among chronic diseases and drugs using factor analysis. Plos One 6;14(2). 2019.

 

2018

Aida Moreno Juste, Antonio Gimeno Miguel, Beatriz Poblador Plou, Francisca González Rubio, María Mercedes Aza Pascual-Salcedo, Enrica Menditto, Alexandra Prados Torres. Adherencia al tratamiento de hipertensión arterial,hipercolesterolemia y diabetes en población anciana de una cohorte española. Medicina Clínica 2018.

Divo MJ, Celli BR, Poblador-Plou B, Calderón-Larrañaga A, de-Torres JP, Gimeno-Feliu LA, Bertó J, Zulueta JJ, Casanova C, Pinto-Plata VM, Cabrera-Lopez C, Polverino F, Carmona Píréz J, Prados-Torres A, Marin JM; EpiChron—BODE Collaborative Group. Chronic Obstructive Pulmonary Disease (COPD) as a disease of early aging: Evidence from the EpiChron Cohort. PLoS One. 2018

Elisa Martín-Merino, Amaia Calderón-Larrañaga, Samuel Hawley, Beatriz Poblador-Plou, Ana Llorente, Irene Petersen, and Daniel Prieto-Alhambra. The impact of different strategies to handle missing data on both precision and bias in a drug safety study: a multi-database multinational population-based cohort study. Clinical Epidemiology 10, 643-654. 2018

Prados-Torres A, Poblador-Plou B, Gimeno-Miguel A, Calderón-Larrañaga A, Poncel-Falcó A, Gimeno-Feliú LA, González-Rubio F, Laguna-Berna C, Marta-Moreno J, Clerencia-Sierra M, Aza-Pascual-Salcedo M, Bandrés-Liso AC, Coscollar-Santaliestra C, Pico-Soler V, Abad-Díez JM. Cohort Profile: The Epidemiology of Chronic Diseases and Multimorbidity. The EpiChron Cohort Study. International Journal Epidemiology 47(2), 382-384 2018

Geurtje Maria Wijers I, Ayala A, Rodriguez-Blazquez C, Rodriguez-Laso A, Rodriguez-García P, Prados-Torres A, Rodriguez-Rodriguez V, Joao Forjaz M. The Disease Burden Morbidity Assessment in older adults and its association with mortality and other health outcomes. European Jourmal of  2018

Davide L Vetrano, Amaia Calderón-Larrañaga, Alessandra Marengoni, Graziano Onder, Jürgen M Bauer, Matteo Cesari, Luigi Ferrucci, Laura Fratiglioni. An international perspective on chronic multimorbidity: approaching the elephant in the room. J Gerontol A Biol Sci Med Sci, Vol. 73, No. 10, 1350-1356. 2018

Enrica Menditto, Caitriona Cahir, Mercedes Aza, Dario Bruzzese, Beatriz Poblador-Plou, Sara Malo, Elisio Costa, Francisca González-Rubio, Antonio Gimeno-Miguel, Valentina Orlando, Przemislaw Kardas, Alexandra Prados-Torres. Adherence in chronic medication in older populations: application of a common protocol among three European Countries. Patient Preference and Adherence 12, 1975-1987. 2018

Jordi Castellsague, Beatriz Poblador‐Plou, Maria Giner‐Soriano, Marie Linder, Oliver Scholle, Brian Calingaert, Christine Bui, Alejandro Arana, Clara Laguna, Francisca Gonzalez‐Rubio, Albert Roso‐Llorach, Alexandra Prados‐Torres, Susana Perez‐Gutthann. Effectiveness of risk-minimization measures for the use of cilostazol in United Kingdom, Spain, Sweden, and Germany. Pharmacoepidemiology & Drug Safety 27(9):953-961. 20

Palmer K,Marengoni AForjaz MJJureviciene ELaatikainen TMammarella FMuth CNavickas RPrados-Torres ARijken MRothe U, Souchet LValderas JVontetsianos TZaletel J14Onder GJoint Action on Chronic Diseases and Promoting Healthy Ageing Across the Life Cycle (JA-CHRODIS). Multimorbidity care model: Recommendations from the consensus meeting of the Joint Action on Chronic Diseases and Promoting Healthy Ageing across the Life Cycle (JA-CHRODIS). Health Policy 122(1):4-11.

2017-2014

2017

Ignatios Ioakeim, Alvaro Irigoyen von Sierakowski, Laura Urieta González, Aida Moreno Juste, Clara Laguna Berna, Francisca González Rubio. Hipovitaminosis D: Buscando la evidencia. Endocrinol Diabetes Nutr. 2017. Nov;64(9):512-513

Alexandra Prados-Torres; Isabel del Cura-González; Daniel Prados-Torres; Juan A López-Rodríguez; Francisca Leiva-Fernández; Amaia Calderón-Larrañaga; Fernando López-Verde; Luis A Gimeno-Feliu; Esperanza Escortell-Mayor; Victoria Pico-Soler; Teresa Sanz-Cuesta; Mª Josefa Bujalance-Zafra; Mariel Morey-Montalvo; José Ramón Boxó-Cifuentes; Beatriz Poblador-Plou; José Manuel Fernández-Arquero; Francisca González-Rubio; María D Ramiro-González; Carlos Coscollar-Santaliestra; Jesús Martín-Fernández; Mª Pilar Barnestein-Fonseca; José María Valderas-Martínez; Alessandra Marengoni; Christiane Muth and Multi-PAP Group. Effectiveness of an intervention for improving drug prescription in primary care patients with multimorbidity and polypharmacy: study protocol of a cluster randomized clinical trial (Multi-PAP project). Implement Sci. 2017 Apr 27;12(1):54.

Luis Andrés Gimeno-Feliu, Amaia Calderón-Larrañaga, Esperanza Díaz, Clara Laguna-Berna, Beatriz Poblador-Plou, Carlos Coscollar, Alexandra Prados-Torres. Multimorbidity and immigrant status: associations with area of origin and length of residence in host country. Family Practice, 2017, 1-5.

Daniel Prados-Torres, Isabel del Cura-González y Alexandra Prados-Torres. Hacia un modelo de atención a la multimorbilidad en atención primaria. Aten Primaria. 2017;49(5):261-262.

Prados-Torres A, Cura-González Id, Prados-Torres JD, Leiva-Fernández F, López- Rodríguez JA, Calderón-Larrañaga A, Muth C. Multimorbilidad en medicina de familia y los principios Ariadne. Un enfoque centrado en la persona .Aten Primaria. 2017;49(5):300-307.

Bousquet J., Bewick M., Cano A. et al. Building bridges for innovation in ageing: Synergies between action group of the EIP on AHA. J Nutr Health Aging. 2017;21(1):92-104.

Jordi Castellsague, Susana Perez-Gutthann, Brian Calingaert, Christine Bui, Cristina Varas-Lorenzo, Alejandro Arana, Alexandra Prados-Torres, Beatriz Poblador-Plou, Francisca Gonzalez-Rubio, Maria Giner-Soriano, Albert Roso-Llorach, Marie Linder, Anna Citarella, Oliver Scholle, Edeltraut Garbe. Characterization of new users of cilostazol in the United Kingdom, Spain, Sweden, and Germany. Pharmacoepidemiology & Drug Safety. 2017 Jun;26(6):615-624.

Amaia Calderón-Larrañaga, Davide L Vetrano, Graziano Onder, Luis A Gimeno-Feliu, Carlos Coscollar-Santaliestra, Angelo Carfí, Maria S Pisciotta, Sara Angleman, René JF Melis, Giola Santoni, Francesca Mangialasche, Debora Rizzuto, Anna-Karin Welmer, Roberto Bernabei, Alexandra Prados-Torres, Alessandra Marengoni, and Laura Fratiglioni. Assessing and measuring chronic multimorbidity in the older population: a proposal for its operationalization. J Gerontol A Biol Sci Med Sci. 2017 Oct

 

2016

Sarría-Santamera A, Hijas-Gómez AI, Carmona R, Gimeno-Feliú LA. A systematic review of the use of health services by immigrants and native populations. Public Health Reviews.2016;37(1):28

Marengoni A , Monaco A ,Costa E,Cherubini A,Prados-Torres A,Muth C, Melis RJ,Pasina L,van der Cammen TJ ,Palmer K,Pecorelli S,Onder G .Strategies to Improve Medication Adherence in Older Persons: Consensus Statement from the Senior Italia Federanziani Advisory Board. Drugs & Aging. 2016 Sep; 33(9):629-37.

Menditto E, Bolufer A, Cahir C, Marengoni A, Riegler S, Fico G, Costa E, Monaco A, Pecorelli S, Pani L, Prados A. Scaling up health knowledge at European level requires sharing integrated data. Clinicoecon Outcomes Res. 2016 Jun 13;8:253-65.

Luis A Gimeno-Feliu, Amaia Calderón-Larrañaga, Esperanza Diaz, Beatriz Poblador-Plou, Rosa Macipe-Costa, Alexandra Prados-Torres. Global healthcare use by immigrants in Spain according to morbidity burden, area of origin, and length of stay. BMC Public Health. 2016 May 27; 16:450.

Malo S, Poblador-Pou B, Prados-Torres A, Lallana MJ, Laguna-Berna C and Rabanaque MJ. Poor congruence with guidelines in the use of antibiotics for acute bronchitis: a descriptive study based on electronic health records. Fam Pract. 2016 Oct;33(5):471-5.

Marengoni, R. J. F. Melis, A. Prados Torres, and G. Onder. Multimorbidity: Epidemiology and Models of Care”. Biomed Res Int, vol. 2016, Article ID 7029027, 2 pages, 2016.

Gimeno LA, Calderón A, Prados A, Revilla C, Diaz E. Patterns of pharmaceutical use for immigrants to Spain and Norway: a comparative study of prescription databases in two European countries. International Journal for Equity in Health. 2016 Feb 24;15:32

Calderón A, Diaz E, Poblador B, Gimeno LA, Abad JM, Prados A. Non-adherence to antihypertensive medication: the role of mental and physical comorbidity. International Journal of Cardiology. 2016 Jan 11; 207:310-316.

Revilla C, Calderón A, Enríquez N, Prados A. Baja concordancia entre la información clínica de atención primaria y hospital. Aten Primaria. 2016 Apr;48(4):244-50.

Machón M, Egüés N, Martínez N, Abellán G, Calderón A, Aldaz P, Poblador B, Vrotsou K, Clerencia M, Prados A, Vergara I. Armonización de bases de datos para el estudio de la fragilidad en personas mayores: Estudio INTAFRADE. Rev Esp Geriatr Gerontol. 2016 Jan-Feb;51(1):29-36.

Marta J, Obón B, Gimeno LA, Achkar N, Poblador B, Calderón A, Prados A. Concordancia del registro de demencia en las principales fuentes de información clínica. Rev Esp Geriatr Gerontol. 2016 Sep-Oct;51(5):276-9.

 

2014

Cimarras C, Calderón A, Poblador B, González F, Gimeno L, Arjol J, Prados A. Association between physical activity, multimorbidity, self-rated health and functional limitation in the Spanish population. BMC Public Health 2014;14:1170.

Calderón A, Soljak M, Cowling T, Gaitatzis A, Majeed A. Association of primary care factors with hospital admissions for epilepsy in England, 2004-10: national observational study. Seizure 2014 Sep;23(8):657-61.

Poblador B, van den Akker M, Vos R, Calderón A, Metsemakers J, Prados A. Similar multimorbidity patterns in primary care patients from two European regions: results of a factor analysis. PLoS One 2014;9(6):e100375.

Abad JM, Calderón A, Poncel A, Poblador B, Calderón J, Sicras A, Clerencia M, Prados A. Age and gender differences in the prevalence and patterns of multimorbidity in the older population. BMC Geriatr 2014;14:75.

Poblador B, Calderón A, Marta J, Hancco J, Sicras A, Soljak M, Prados A. Comorbidity of dementia: a cross-sectional study of primary care older patients. BMC Psychiatry 2014;14(1):84.

Calderón A, Soljak M, Panna Vamos E, Cecil E, Valabhji J, Bell D, Abi-Aad G, Prados A, Majeed A. Does higher quality of primary healthcare reduce admissions for diabetes complications? A national observational study. Diabet Med 2014;31(6):657-65.

Prados A, Calderón A, Hancco J, Poblador B, van den Akker M. Multimorbidity patterns: a systematic review. J Clin Epidemiol. 2014;67(3):254-66.

Aguilar I, Carrera P, Poblador B, Prados A, Rabanaque M, por (GRISSA). Morbilidad y consumo de fármacos. Comparación de resultados entre la Encuesta Nacional de Salud y los registros electrónicos. Gac Sanit. 2014;28(1):41-7.

Proyectos activos

  • Características clínico-epidemiológicas del COVID-19 en Aragón. Caracterización de grupos de riesgo e incidencia de morbilidad y mortalidad (PRECOVID Study)
  • Study on impact of COVID-19 infection and medicines in pregnancy (CONSIGN)
  • Strengthening use of real-world data in medicines development – metadata for data discoverability and study replicability
  • CONCEPT-SURBCAN: uso de datos del mundo real para estudiar la efectividad y la eficiencia de la atención a supervivientes de cáncer de mama de larga duración
  • Proyecto FIS Multicéntrico: “Efectividad de la intervención Multi-PAP Plus en ancianos jóvenes con multimorbilidad y polimedicación para mejorar la prescripción en atención primaria: ECA por conglomerados (PI18/01303)
  • FAIR4Health: Improving Health Research in EU through FAIR Data
  • EU Joint Action: CHRODIS-PLUS Implementing good practices for chronic diseases
  • Cross National Comparison on Medication Adherence based on Observational Database. EIP-AHA
  • Proyecto FIS Multicéntrico: “Efectividad de la intervención Multi-PAP en ancianos jóvenes con multimorbilidad y polimedicación para mejorar la prescripción en atención primaria: ECA por conglomerados (PI15/00276)”
  • Red de Investigación en Servicios de Salud en Enfermedades Crónicas (REDISSEC RD16/0001/0005). ISCIII. Programa RETICs
  • Reconocimiento como Grupo de Referencia del Gobierno de Aragón del Área de Biomédicas

Actividad y resultados más relevantes del año

A nivel europeo, EpiChron está trabajando en cuatro proyectos sobre efectividad y seguridad de las vacunas de COVID19 a través de su participación en VAC4EU. Además, ha trabajado en su incorporación a la Joint Action de Enfermedades Cardiovasculares y Diabetes (JACARDI). A nivel nacional, el grupo coordina el ensayo clínico MULTIPAP Plus sobre multimorbilidad y polifarmacia, galardonado en los premios 20 años IACS como “Iniciativa pionera de investigación”; participa en el proyecto CONCEPT-SURBCAN sobre cáncer de mama, y forma parte de las Redes de investigación de Cronicidad, Atención Primaria y Promoción de la Salud (RICAPPS) y de Servicios de Salud en Enfermedades Crónicas (REDISSEC). Asimismo, ha conseguido financiación en la convocatoria AES 2022 para estudiar las trayectorias de multimorbilidad en el SNS a través de un proyecto multicéntrico en siete comunidades autónomas.

EpiChron ejerce una importante labor formativa, siendo Unidad acreditada del Dispositivo Docente para formación especializada MIR de MPySP. Se ha defendido una tesis doctoral y tres están en desarrollo, y se han tutorizado 2TFM, 1TFG y 1TFD. Además, se ha iniciado un programa formativo propio sobre multimorbilidad con el fin de actualizar al personal sanitario e investigador sobre las últimas evidencias en relación al paciente con multimorbilidad. La primera edición “Desafío en multimorbilidad: Aplicabilidad potencial de los resultados de la investigación” fue acreditada con 1,9 créditos por la CFC.

En lo relativo a Recursos Humanos, el Grupo tiene activo un contrato Río Hortega, y ha conseguido 3 contratos de apoyo a la investigación, dos de ellos asociados a la Red RICAPPS del ISCIII y uno obtenido con fondos propios del Grupo. Un hito importante ha sido la concesión de un contrato Juan Rodés en la convocatoria AES 2022. Además, ha seguido realizando intensificaciones de sus miembros asistenciales, para promover la investigación entre profesionales sanitarios del SALUD mediante una liberación parcial de su labor asistencial.

Fecha actualización

Noviembre 2023